Epilepsy & the Endocannabinoid System

Evidence of cannabis being used in the treatment of seizure disorders dates back thousands of years, and cannabis preparations had a role in the treatment of epilepsy by neurologists in the late nineteenth century. A clinical trial conducted in 2016 provided the first Class 1 evidence that CBD improves seizure control in patients with epilepsy syndromes. The review featured below contextualizes that trial, alongside analyses of other cannabinoid studies, within epilepsy research as a whole. The promising mechanics of several epilepsy-combatant cannabinoids including CBD, THCA, and CBDV are also outlined. After almost four millennia of its documented medical use in the treatment of seizure disorders, we are very close to obtaining conclusive evidence of cannabis’s efficacy in severe epilepsy syndromes.

Access the full review here: https://www.j-epilepsy.org/journal/view.php?doi=10.14581/jer.17012